IVF MORE®: In Vitro Fertilization with Oocyte Restoration
Opening New Possibilities in Assisted Reproduction
IVF MORE® (Magnetic Ovulatory Restoration) goes beyond traditional in vitro fertilization (IVF) procedures, marking a new era in fertility treatment.
This exclusive technique is designed for women who wish to conceive with their own eggs, facing challenges related to oocyte quality due to:
- Advanced maternal age
- Endometriosis
- Polycystic Ovary Syndrome (PCOS)
- Repeated failed IVF cycles
The Critical Role of Oocytes
Oocytes are not only carriers of half the essential genetic material for creating life but also play a key role in early embryonic development. Their cytoplasm, rich in nutrients and metabolic factors, determines embryo viability and the success of conception.
Age, PCOS, endometriosis, and other factors can compromise oocyte quality. IVF MORE® restores and optimizes cellular function, giving a real chance of pregnancy with a woman’s own eggs.
What is IVF MORE®?
IVF MORE® is a patented oocyte restoration treatment that combines advanced biotechnology, micromanipulation, and magnetic fields to improve egg quality and embryonic development, without altering the patient’s genetic material.
Unlike egg donation, IVF MORE® preserves genetic identity while restoring metabolism, energy, and cellular structure of the oocyte.
Factors Affecting Oocyte Quality
- Energy deficit (ATP) preventing proper cell division
- Oxidative stress damaging DNA and mitochondria
- Cytoskeleton disorganization, critical for genetic division
- Chromosomal errors increasing risk of miscarriage or implantation failure
How IVF MORE® Works: Step by Step
- Personalized Medical Consultation: Comprehensive assessment to define the optimal treatment plan.
- Ovarian Stimulation and Egg Retrieval: Ovaries are stimulated to produce eggs. A single mature oocyte is sufficient to continue. Eggs are vitrified alongside sperm (if applicable).
- Oocyte Metabolic Assessment: Each egg undergoes metabolic and mitochondrial evaluation to identify energy deficits.
- References:
- Aging and oxidative stress: PubMed 34121193
- Metabolic dysregulation in low ovarian reserve: Zhu et al., 2023
- References:
- Personalized Cytoplasmic Restoration: Infusion of energy and mitochondrial factors revitalizes the egg. Donor cytoplasm may be used when necessary without altering the patient’s DNA.
- Advanced Sperm Selection & Fertilization (ICSI / PICSI): High-quality sperm is selected using advanced techniques and injected into the restored oocytes
- Embryo Culture in Magnetic Fields: Embryos develop in a specialized magnetic environment that:
- Reorganizes the cytoskeleton
- Optimizes mitochondrial distribution
- Activates essential ion channels
- Reduces unnecessary energy expenditure
- Reference: Magnetic Fields – Nature
Embryo Transfer: Viable embryos are transferred to the uterus. Regenerative treatments, such as Endogen®, may be used if endometrial receptivity is low.
Who Can Benefit?
IVF MORE® is indicated for women who:
- Are 35+ with low oocyte quality
- Have endometriosis
- Present PCOS or blocked embryos
- Experienced repeated IVF failures
- Want to use frozen eggs and improve quality before fertilization
Proven Results
- Higher rates of viable embryos: up to 3x more than non-restored eggs
- Reduced genetic risk: chromosomal abnormalities reduced from 82% → 26
Increased implantation & pregnancy rates: women >40 can achieve pregnancy with their own restored eggs
Complementary Treatments
Ovagen® – Enhancing Ovarian Function
- Reactivates ovarian function and increases viable egg count
- Uses patient-derived growth factors (PRP) and bio-stimulants
- Complements IVF MORE® by boosting oocyte quantity and quality
Endogen® – Optimizing Endometrial Receptivity
- Improves endometrial thickness, vascularization, and cellular receptivity
- Uses PRP and, when necessary, mesenchymal stem cells
- Enhances implantation of restored embryos
Limitations
- Requires at least one mature oocyte
- If no viable eggs are available, the technique cannot be performed; egg donation may be considered
If the patient’s egg lacks sufficient capacity, donor cytoplasm may be used without altering nuclear DNA
Who Can Benefit from IVF MORE?
IVF MORE® offers a valuable alternative for individuals facing significant fertility challenges.
How Was IVF MORE® created?
IVF MORE® was born from the dedication of researchers who discovered that egg quality deteriorates with age due to mitochondrial dysfunction. Then, our Regenera team identified key metabolites and factors linked to the egg’s energetic and metabolic performance, leading to their proprietary formula, IVF MORE®.
By using the patient’s mitochondria to revitalize the eggs and employing magnetic fields in embryonic culture, they facilitated proper cell division, significantly increasing the chances of obtaining viable embryos. This combination of metabolic diagnosis, egg revitalization, and magnetic fields has set a new precedent in assisted reproduction.
IVF MORE® offers new hope to women with poor egg quality, including those with endometriosis and polycystic ovary syndrome, by reducing genetic errors and improving success rates in embryo development. This innovative solution provides an alternative for women who do not want to opt for egg donation, significantly improving the chances of successful pregnancies.
Overcoming Fertility Barriers Beyond Age
Although IVF success rates decrease after 35 years of age, IVF MORE® offers an innovative technique that enhances the fertilization process. This technique improves the chances of conceiving your eggs without resorting to egg donation. Instead of relying on younger donor eggs, IVF MORE® helps overcome the challenges of age, endometriosis, and PCOS, providing new hope for achieving a successful pregnancy.
How Does IVF MORE® Define Success in Fertility?
At IVF MORE®, we understand how challenging it can be to achieve a viable embryo. In patients where ovarian restoration could not be achieved in a single attempt, it usually occurred because they had few eggs. But in up to 85% of cases, we have achieved viable embryos for transfer. In some cases, we had to repeat, but in most cases, we achieved a viable embryo.
Our technique adds the necessary metabolites, growth factors, and energy components for the correct metabolism of the egg’s cytoplasm with a patented recipe, improving its quality. We adapt each treatment to the specific needs of your eggs, optimizing their chances of restoration and embryo development.
With IVF MORE®, we are here to accompany you every step of this exciting journey, offering you a real opportunity to fulfill your dream of becoming a mother.
